Figure 6.

Simplified community network map with inter-community crosstalk in (A) ROCs^R1441C-GDP, (C) ROCs^R144G-GDP, and (E) ROCs^R144H-GDP. Cartoon diagrams with residues color-coded by their corresponding community partition were made transparent as the background to indicate the spatial position of each community. A schematic diagram of allosteric signaling between the mutated site at position 1441 and the nucleotide-binding motifs Gnt1 and Gnt2 (marked with cyan and orchid dotted lines) in (B) ROCs^R1441C-GDP, (D) ROCs^R144G-GDP, and (F) ROCs^R144H-GDP mutants. Secondary structures of ROC^A are represented by colored hollow rectangles, and ROC^B components are shown in filled ovals. The gray and pink arrows, respectively, indicate allosteric signals from the mutation site on ROC^A and ROC^B, and black arrows denote paths involved in transmitting signals from both mutation sites. Note that all arrows here are one-ended for clarity; the actual information flow can pass in both directions for reversible communication.