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Increased lactate production in macrophages has no effect on Salmonella enterica serovar Typhi (S. Typhi) intracellular replication. (A) Replication of wild-type S. Typhi and ΔlldP mutant strain that cannot utilize lactate in THP-1 cells. (B) Replication of S. Typhi in 0, 6, or 12 mM lactate-treated THP-1 cells. (A,B) Data were obtained from three independent experiments and analyzed using Student’s t-test. ns, not significant.
