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. 2021 Sep 16;22(18):10003. doi: 10.3390/ijms221810003

Figure 5.

Figure 5

Increased macrophage glucose levels contribute to intracellular replication of S. enterica serovar Typhi (S. Typhi). sh-slc2a1 represents treatment with lentiviral short hairpin RNA (shRNA) to reduce intracellular glucose levels in human macrophage cell line THP-1 (A) Glucose levels of sh-slc2a1 and sh-control-treated THP-1 cells. (B) Replication of S. Typhi in sh-slc2a1 or sh-control-treated THP-1 cells. (C) Replication of S. Typhi in the presence of 0 mg/mL, 1 mg/mL, or 2 mg/mL glucose, in THP-1 cells. (D) Replication of S. Typhi in the presence of 0 mg/mL, 1 mg/mL, or 2 mg/mL glucose, in sh-slc2a1 treated THP-1 cells. (A–D) Data were obtained from three independent experiments and analyzed using Student’s t-test. * p < 0.05; ** p < 0.01; **** p < 0.0001.