Figure 2.

A maternal high-fat diet (HFD) during pregnancy and lactation changes the level of proteins associated with autism spectrum disorder (ASD) in the frontal cortex and hippocampus of adolescent offspring. (a) Effects of maternal HFD on ANKRD11, EIF4E, NF1, SETD1B, SHANK1, and TAOK2 protein levels in the frontal cortex of male and female offspring at PND 28. (b) Effects of maternal HFD on ANKRD11, EIF4E, NF1, SETD1B, SHANK1, and TAOK2 protein levels in the hippocampus of male and female offspring at PND 28. The results are expressed as the mean (±SEM). n = 8 rats/group. Data were analyzed by two-way ANOVA followed by Bonferroni post hoc test. * p < 0.05, ** p < 0.01, *** p < 0.001 versus the standard diet (SD) group.