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. 2021 Sep 16;13(9):3212. doi: 10.3390/nu13093212

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A maternal high-fat diet (HFD) during pregnancy and lactation changes the level of proteins associated with autism spectrum disorder (ASD) in the hippocampus of young adult offspring. (a) Effects of maternal HFD on ANKRD11, EIF4E, NF1, SETD1B, SHANK1, and TAOK2 protein levels in the frontal cortex of male and female offspring at PND 63. (b) Effects of maternal HFD on ANKRD11, EIF4E, NF1, SETD1B, SHANK1, and TAOK2 protein levels in the hippocampus of male and female offspring at PND 63. The results are expressed as the mean (±SEM). n = 7 rats/group. Data were analyzed by two-way ANOVA followed by Bonferroni post hoc test. * p < 0.05 versus the standard diet (SD) group.