Table A1.

Table showing the range of treatments administered across all papers on an individual basis alongside reported outcome.

Treatment/Intervention	Administered n	Positive Response	Negative Response	No Response
SSRI—fluvoxamine	5	3 “Symptoms improved” “Moderate improvement” “Significantly better”	0	2 “No improvement” “No change”
Amantadine	2	2 “Partial improvement” “Partial improvement”
Levomepromazine	2	2 “Partial improvement” “Partial improvement”
Haloperidol	4	3 “Improvement” “Partially improved” “Improvement for 6 months”		1 “Unsuccessful”
Mexazolam	1	1 “Improvement”
Bromazepam	1	1 “Partial improvement”
Carbamazepine	2	1 “Partial improvement”		1 “Unsuccessful”
Clomipramine	4	3 “Partial improvement” “Partial improvement” “Complete recovery” “Slight improvement, side effects”
Romethazine	1	1 “Partial improvement”
Lorazepam	10	4 “Partial improvement” “80% return to baseline” “Responded to” “Showed increase” “Significant improvement”	1 “Negative effects”	5 “No consistent improvement” “No consistent improvement” “No consistent improvement” “No change” “Ineffective”
Methylprednisolon	3	3 “Dramatic improvement” “Immediate improvement” “Many behaviours resolved”
IVIG	4	4 “Full recovery” “Steady improvement” “Lots of symptoms resolved” “Resolution of everything except insomnia”
Mycephenolate	1			1 Discontinued no data
Oral steroid	2	2 “Immediate improvement” “Lots of resolved symptoms”
Rituximab	1	1 “Improvement”
Electro-convulsive therapy	10	10 “Some behaviours completely resolved” “Complete recovery” “Complete recovery” “Complete recovery” “Complete recovery” “Robust response” “Significant improvement” “Return to almost baseline” “Excellent response” Strong response”
Benzodiazepines	1	1 “Partial improvement”
Anti depressants	1	1 “Steady return to baseline”
Positive airway pressure for obstructive sleep apnoea	1	1 “Steady return to baseline”
Psychological support	2	2 “Steady return to baseline” “Moderate improvement for 6 months”
Donepezil	1	1 “Return to baseline”
Acetylcholinesterase inhibitor	1	1 “Return to baseline”
Bupropion	1		1 “Worsening of catatonia and further decline”
Trazodone	4	1 “Some improvement”	2 “Worsening of catatonia and further decline” “Worsening and decline”	1 “Unsuccessful”
Olanzapine	1		1 “Worsening of catatonia and further decline”
Aripiprazole	1		1 “Worsening of catatonia and further decline”
Ziprasidone	1		1 “Worsening of catatonia and further decline”
Lithium	3	1 “Improvement”	1 “Worsening of catatonia and further decline”	1 “No improvement”
Clozapine	1	1 “85% return to baseline”
Desipramine	6	1 “Moderate improvement for 6 months”	1 “Worsening of symptoms”	4 “No change” “No effect” “Unsuccessful” “Unsuccessful”
Thiothixine	2	1 “Complete recovery”		1 “No change”
Amitriptyline	1	1 “Complete recovery”
Nortriptyline	1			1 “Unsuccessful”
Clonazepam	2	1 “Partial improvement”		1 “Unsuccessful”
Ethosuximide	1			1 “No effect”
Lidexamfetamine	1		1 “Worsening”
SSRI citalopram	1		1 “Worsening”
Amiloride	1	1 “Improvement”
Lamotrigine	1			1 “No effect”
Antipsychotic treatment	1	1 “Good response”

Note: dosages and additional medications/treatments are not reported.