Table 2.
Rate ratios of hospital contacts (RRs) and 95% confidence intervals (CIs) for all survivors of malignant bone tumors and for the sub-cohorts of survivors of osteosarcoma and Ewing sarcoma compared with the matched comparison cohort, stratified by sex, age at diagnosis, year of diagnosis, years since diagnosis, and cancer site.
| All Survivors of Malignant Bone Tumors | p-Value | Osteosarcoma | Ewing Sarcoma | ||||
|---|---|---|---|---|---|---|---|
| Observed Number of Hospital Contacts | RR (95% CI) | Observed Number of Hospital Contacts | RR (95% CI) | Observed Number of Hospital Contacts | RR (95% CI) | ||
| Overall | 537 | 1.80 (1.56 to 2.08) | 386 | 1.67 (1.41 to 1.98) | 151 | 2.24 (1.76 to 2.85) | |
| Test for same effect in survivors of osteosarcoma and Ewing sarcoma | 0.044 | ||||||
| Sex | |||||||
| Men | 302 | 2.08 (1.69 to 2.56) | 210 | 1.91 (1.50 to 2.42) | 92 | 2.63 (1.85 to 3.73) | |
| Women | 235 | 1.54 (1.26 to 1.87) | 176 | 1.46 (1.16 to 1.84) | 59 | 1.82 (1.37 to 2.42) | |
| Test for interaction * | 0.038 | ||||||
| Age at diagnosis (years) | |||||||
| 0–14 | 299 | 1.64 (1.36 to 1.98) | 198 | 1.51 (1.20 to 1.89) | 101 | 1.99 (1.48 to 2.67) | |
| 15–19 | 238 | 2.05 (1.63 to 2.58) | 188 | 1.90 (1.47 to 2.45) | 50 | 2.93 (1.89 to 4.54) | |
| Test for interaction * | 0.138 | ||||||
| Period of diagnosis | |||||||
| 1961–1969 | 54 | 3.54 (1.84 to 6.80) | 44 | 3.13 (1.48 to 6.59) | 10 | 8.19 (5.37 to 12.47) | |
| 1970–1979 | 174 | 1.47 (1.15 to 1.86) | 117 | 1.30 (0.98 to 1.71) | 57 | 1.99 (1.34 to 2.95) | |
| 1980–1989 | 163 | 1.69 (1.31 to 2.17) | 127 | 1.65 (1.23 to 2.21) | 36 | 1.87 (1.30 to 2.67) | |
| ≥1990 | 146 | 2.17 (1.69 to 2.79) | 98 | 2.02 (1.53 to 2.67) | 48 | 2.58 (1.63 to 4.08) | |
| Test for interaction * | 0.025 | ||||||
| Time since diagnosis (years) | |||||||
| 5–9 | 185 | 2.14 (1.73 to 2.64) | 127 | 1.94 (1.53 to 2.46) | 58 | 2.76 (1.90 to 4.03) | |
| 10–19 | 160 | 1.44 (1.16 to 1.79) | 113 | 1.34 (1.03 to 1.74) | 47 | 1.74 (1.26 to 2.41) | |
| ≥20 | 192 | 1.92 (1.50 to 2.45) | 146 | 1.80 (1.36 to 2.39) | 46 | 2.40 (1.59 to 3.62) | |
| Test for interaction * | 0.016 | ||||||
| Cancer site | |||||||
| Extremities | 412 | 1.75 (1.48 to 2.08) | 320 | 1.66(1.37 to 2.01) | 92 | 2.16 (1.57 to 2.98) | |
| Axial skeleton | 125 | 1.98 (1.56 to 2.53) | 66 | 1.73(1.27 to 2.37) | 59 | 2.37 (1.67 to 3.36) | |
| Test for interaction * | 0.394 | ||||||
* Test for common effect, whether the effect of being a survivor of a malignant bone tumor is the same in men and women, across different age groups at diagnosis, different period of diagnosis, different time intervals since diagnosis, or in different cancer sites.