Table 1.

Table summarizing SIRT7 nucleolar functions under physiological and stress conditions.

SIRT7 Nucleolar Functions
Function	Cell Type	Condition
Stimulation of rDNA transcription and ribosome biogenesis	Cancer cell lines and human embryonic kidney cells	Physiological conditions [27,28,29,30,31].
Maintenance of rDNA repeats integrity	Primary mouse embryonic fibroblasts (MEFs), mouse liver, human fibroblast-like fetal lung cells	Physiological conditions [22,47].
Resolution of R-loops	Cancer cell lines and human embryonic kidney cells	Physiological conditions [53].
Stabilization of p53 through NPM deacetylation	Cancer cell lines, MEFs, mouse skin	UV irradiation [17]
Stabilization of p53 through MDM2 degradation	Cancer cell lines	glucose starvation [59]
Inhibition of pre-rRNA transcription following stress	Cancer cell lines and human embryonic kidney cells	Nutrient stress [28,66]. hypertonic stress [31].