Figure 1.
An overview of the immune exhaustion process occurring in PLWHIV. (PD-1, programmed death cell protein-1; CTLA-4, anti-cytotoxic T-lymphocyte-associated protein 4; TIM-3, T cell immunoglobulin and mucin domain-containing protein 3; TIGIT, T cell immunoreceptor with Ig and ITIM domains; LAG-3, lymphocyte-activation gene 3; PD-L1, PD-1 ligand 1; APC, antigen-presenting cell; IL-10, interleukin 10; IFN-γ, interferon gamma; TNF, tumor necrosis factor; IL-2 interleukin 2).