Table 1.
Summary of the pharmacokinetic parameters of PTX in the presence and absence of PEs with single/multiple-dose administration.
| Compound, Dose, Route | PK Parameters, Mean ± SD, n = 6 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| t1/2 | k | Cmax | Vd | AUC(0-last) | AUC(0-inf) | CL | MRT(0-inf) | ||
| h | 1/h | ng/mL | mL/kg | h × ng/mL | h × ng/mL | mL/h/kg | h | ||
| single-dose | PTX 3 mg/kg, iv + saline, iv | 8.8 ± 0.9 | 0.08 ± 0.01 | 933.0 ± 237.1 | 16,682.8 ± 2797.0 | 1443.3 ± 133.9 | 1653.8 ± 160.4 | 1827.8 ± 178.6 | 10.1 ± 1.1 |
| PTX 3 mg/kg, iv + Tween 80, 180 mg/kg, iv | 9.7 ± 3.1 | 0.08 ± 0.03 | 951.4 ± 134.6 | 18,030.3 ± 4788.1 | 1338.4 ± 257.3 | 1564.7 ± 368.4 | 1986.7 ± 370.5 | 10.4 ± 3.3 | |
| PTX 3 mg/kg, iv + EL−35, 430 mg/kg, iv | 10.0 ± 2.8 | 0.07 ± 0.02 | 985.4 ± 287.6 | 18,964.5 ± 5006.2 | 1338.8 ± 258.9 | 1574.0 ± 342.6 | 1995.7± 524.5 | 11.0 ± 3.4 | |
| 14-days | PTX 3 mg/kg, iv + saline, iv | 10.9 ± 4.6 | 0.07 ± 0.03 | 1057.0 ± 326.3 | 22,084.5 ± 8607.9 | 1146.4 ± 280.0 | 1379.4 ± 393.0 | 2313.8 ± 599.5 | 11.9 ± 4.3 |
| PTX 3 mg/kg, iv + Tween 80, 180 mg/kg, iv | 11.2 ± 1.5 | 0.06 ± 0.01 | 1079.5 ± 471.1 | 22,407.0 ± 5218.8 | 1162.6 ± 223.9 | 1402.2 ± 276.8 | 2212.8 ± 447.1 | 11.9 ± 1.3 | |
| PTX 3 mg/kg, iv + EL−35, 430 mg/kg, iv | 20.4 ± 3.1 ** | 0.03 ± 0.01 ** | 1240.0 ± 181.2 | 21,207.4 ± 3102.1 | 2153.3 ± 316.6 ** | 3350.7 ± 674.4 ** | 923.4 ± 170.0 ** | 23.4 ± 4.0 ** | |
** p < 0.01, against saline control.