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Cytotoxic effect of free RA (A), and RA-SFNs (B) on HeLa and MCF-7 cell lines. Data are expressed as percentage of cell viability ± SD vs. concentration. * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001 and **** indicates p < 0.0001, compared to control. SFNs without drug were tested at the highest concentration of RA-SFNs (3.5 mg/mL).
