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KD Determination of additional analogs containing the main scaffold.
| |||
|---|---|---|---|
| Compound | R1 | R2 | KD (µM) |
| 5 | -OH (p) | -4-CH3 | 48 ± 21 |
| 6 | -OH (p) | -2,3-Cl | 90 ± 4 |
| 7 | -OH (p) | -2-CH3 | 41 ± 18 |
| 8 | -OH (p) | -2,5-CH3 | 11 ± 5 |
| 9 | -OH (p) | -4-CH2CH3 | 125 ± 20 |
| 10 | -OH (p) | -3-CH3 | NB a |
| 11 | -OH (p) | -3-CF3 | NB a |
| 12 | -OH (p) | -4-CF3 | 48 ± 24 |
| 13 | -OH (m) | -2,4-CH3 | 77 ± 15 |
| 14 | -CH2OH (m) | -3-CH3 | 38 ± 5 |
a NB: No binding.
