Table 1.
The physiological parameters of 5/6 nephrectomy animals revealed accumulation of blood urea nitrogen (BUN), creatinine, indoxyl sulfate (IS), and p-cresol sulfate (PCS) in the circulation system. a, p < 0.05 vs. control-4W; b, p < 0.05 vs. control-8W.
| Sham-Operation | 5/6Nx | |||
|---|---|---|---|---|
| Post-Surgery Time | Control-4W | Control-8W | CKD-4W | CKD-8W |
| Animal Number | N = 8 | N = 8 | N = 8 | N = 8 |
| Body Weight (g) | 29.5 ± 2.1 | 29.9 ± 0.8 | 25.7 ± 0.6 | 27.9 ± 0.8 |
| BUN (mg/dL) | 24.3 ± 5.0 | 20.6 ± 4.9 | 53.5 ± 12.3 a | 47.7 ± 8.6 b |
| Creatinine (mg/dL) | 1.03 ± 0.15 | 1.12 ± 0.23 | 1.85 ± 0.38 a | 2.35 ± 0.47 b |
| Indoxyl sulfate (ng/mL) | 5142.4 + 1660.0 | 4343.95 ± 2481.2 | 18,959.7 ± 5072.2 a | 18,152.5 ± 8887.5 b |
| P-cresyl sulfate (ng.mL) | 1794.9 ± 372. | 2423.3 ± 900.3 | 6413.5 ± 2184.4 a | 3892.7 ± 2822.5 b |