Figure 1.

Channel families-the composition of dataset. All of the sequences have been extracted from the Swiss-Prot [26]. Potassium channels represent both the different families and the topologies of the known channels. Non-potassium channels here have been used as the false positives. All of the sequences having >80% sequence-similarity have been removed. The remaining channel numbers are in brackets. The (2 + 2) channels’ double-pore consists of 2 α-subunits having 4 transmembrane domains each. The α-subunits of the (6 + 2) channels with double-pore possess 8 transmembrane domains. Ambiguity exists in 3 unclassified potassium-channels classification.