Figure 12.

“Patch-clamp” data were produced from two different stochastic models. (A,C) The Markovian models simulating the ion channel data. Ion channels move between closed (0 conductance) and open (unitary-conductance, g) states. In many cases, there are many open and closed states (“O1”–“O3”, or “C1”–“C3”, respectively). The central dogma of ion channel research is that the g will be the same for O1, O2, or O3. Although substates have been identified in some situations, these are beyond the scope of our current work. (A) Model M1; the stochastic model from ref. [68] and its output. (B) It has a low open probability, so the data is a representation of the 0 or a channel openning state. (C) Model M2; the stochastic model, and an output data (D) since the open probability is high, the signal is found to be largely composed of 3 or more ion channels that are simultaneously open.