Figure 3.

Electron micrograph of the cardiac muscle of different groups. (A) Control heart showing normal myocyte. (B) G1-treated showing myofibrillar disorganization and marked myofilament lysis. (C) G2-treated showing marked perinuclear myofilamental lysis. (D) G3-treated showing a severe degree of myolysis. (E) G4-treated showing disorganized myofibrils and bundles with marked collagen fiber proliferation separating two myocytes. (F) G5-treated showing bundles of collagen fiber interposed by interstitial cells. (G) G6-treated showing advanced interstitial fibrosis exemplified by large bundles of collagen fibers and perivascular edema with distortion of some myofibrils, occasional sarcoplasmic vacuolation, and severe mitochondrial damage. (H) G7-treated showing perivascular edema and fibrosis associated with the presence of degranulated mast cells. Bar = 2 µm. N = nucleus. MF = myofibrils. M = mitochondria. CL = collagen fibers. IC = interstitial cell. V = vacuole. BV = blood vessel. MC = mast cell.