Figure 3.

Kaplan–Meier curve of event-free survival for the most significant gene of each CRC STN. The most significant gene in each signalling pathway from the RNA Sequencing TCGA legacy dataset was (A) DVL3 for WNT STN, (B) EFNA1 for PI3K-Akt STN, (C) BCL2 for TP53 STN, (D) KRAS for MAPK STN, and (E) TERT for TGF-Beta STN. The patients were stratified into two groups according to the expression level of each feature. The optimal cut-off was determined using Kaplan–Meier scanning (see Methods). The groups are represented as high (orange line), and low (blue line), where n indicates the total number of patients in each group. For each group, the Kaplan–Meier curve of event-free survival was tested for statistically significant differences using a log-rank test. ${\mathrm{Log}}_2\mathrm{HR}$ = log base 2 of the hazard ratio. ${\mathrm{CI}}_{95\%}$ = 95% Confidence Interval. P-val = p-value.