Table 2.

Indications of mirtazapine in neuropsychiatric disorders that do not include MDD.

Indication	Description
Insomnia	Decreases REM sleep, improves the quality of sleep and sleep continuity [95]
Panic disorder	Decreases agitation and panic attacks; Can be a fast and effective alternative to SSRIs [96,97]
Post-traumatic stress disorder (PTSD)	Effective and well-tolerated [98]; Effective in PTSD related to combat [99]
Obsessive-compulsive disorder (OCD)	Effective with continuous treatment [100]; Fast action, more effective and fewer side effects when added to citalopram [101]
Anxiety disorders	Effective and earlier-onset action (vs. paroxetine) [102]; Effective in reducing generalized anxiety [103]; Lack of efficiency in social anxiety disorder (vs. placebo) [104]
Migraine	Prevents migraine initiation and treats this condition [105]; However, side effects of mirtazapine’s use include headaches [106]. Thus, there is a lack of consistent evidence