Table A3.

Biomarker assessments—individual participant data.

Participant	5-HTOL		5-HIAA		5-HTOL/5-HIAA Ratio
	Control Day	Alcohol Day	Control Day	Alcohol Day	Control Day	Alcohol Day
Unit	ng/mL	ng/mL	µg/mL	µg/mL	(ng/mL/µg/mL) × 1000	(ng/mL/µg/mL) × 1000
1	3.56	153.93	2.54	3.42	1.40	44.94
2	16.38	74.89	5.66	5.63	2.89	13.31
3	14.21	13.03	4.32	3.03	3.29	4.30
4	8.06	14.06	0.72	1.78	11.21	7.91
5	17.29	49.00	2.93	3.28	5.91	14.95
6	5.18	633.47	1.04	4.01	5.00	157.97
7	15.26	159.08	2.45	2.06	6.23	77.15
8	13.03	1239.32	3.22	3.72	4.05	333.37
9	34.00	40.82	5.19	4.82	6.55	8.47
10	31.28	97.92	4.73	5.10	6.62	19.19
11	4.01	22.80	0.62	0.65	6.44	35.30
12	7.13	468.57	0.76	3.69	9.43	126.85
13	39.53	16.08	9.22	3.21	4.29	5.02
14	6.76	323.34	1.79	1.33	3.78	243.58
15	12.86	7.12	4.12	0.55	3.12	12.85
16	39.96	56.41	9.77	4.05	4.09	13.92
17	36.44	21.73	7.64	3.07	4.77	7.09
18	15.13	801.49	1.27	2.74	11.89	292.52
19	32.70	557.34	9.14	5.79	3.58	96.25
20	16.78	33.14	7.19	8.57	2.34	3.87
21	27.62	662.81	3.31	2.79	8.36	237.91
22	38.60	1332.52	6.74	4.39	5.72	303.41
23	60.74	1088.98	7.77	4.68	7.85	232.78
24	34.18	59.96	4.47	5.15	7.65	11.63
25	26.25	147.12	5.42	3.28	4.84	44.88
26	9.66	1051.86	4.75	3.33	2.03	316.18
27	ND	259.72	2.73	5.75	ND	45.17
28	3.17	ND	0.41	3.13	7.71	ND
29	15.68	26.00	6.47	7.86	2.42	3.31
30	13.67	1824.73	1.26	5.27	10.85	346.45
31	11.31	109.05	1.51	4.02	7.48	27.12
32	3.46	16.36	0.52	0.48	6.64	33.90
33	21.83	94.45	1.94	4.66	11.26	20.27
34	21.18	376.20	5.27	2.14	4.02	176.07
35	4.20	ND	0.76	7.36	5.52	ND

ND = not determined. Abbreviations: 5-HTOL = 5-hydroxytryptophol, 5-HIAA = 5-hydroxyindoleacetic acid.