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. 2021 Aug 25;10(9):1342. doi: 10.3390/antiox10091342

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Schematic representation of the mixed inhibition of IDE-dependent degradation of insulin by EGCG. EGCG binds to either IDE or IDE●insulin complex, leading to a decrease in catalytic activity.