Table 4.
Properties of compacts.
Measured Value | CP [MPa] | Cellactose® 80 | CombiLac® | MicroceLac® 100 | StarLac® |
---|---|---|---|---|---|
UM [mg] | 78 | 198.81 ± 1.50 | 197.66 ± 7.57 | 199.78 ± 1.35 | 199.25 ± 0.93 |
130 | 199.20 ± 0.74 | 198.08 ± 2.75 | 200.70 ± 0.34 | 197.73 ± 1.98 | |
182 | 196.96 ± 4.35 | 198.96 ± 2.22 | 199.51 ± 0.43 | 196.48 ± 2.57 | |
78 | - | - | - | - | |
RMS [nm] | 130 | - | - | - | - |
182 | 202.13 ± 122.59 | 196.08 ± 91.94 | 130.58 ± 76.30 | 180.85 ± 119.66 | |
PD [g/cm3] | 78 | 1.55088 ± 0.0004 | 1.54436 ± 0.0001 | 1.5536 ± 0.0002 | 1.53477 ± 0.0012 |
130 | 1.54804 ± 0.0004 | 1.54201 ± 0.0001 | 1.5501 ± 0.0002 | 1.53629 ± 0.0009 | |
182 | 1.54662 ± 0.0002 | 1.543001 ± 0.0003 | 1.5542 ± 0.0002 | 1.53819 ± 0.0011 | |
Po [%] | 78 | 25.56 ± 2.27 | 23.45 ± 2.05 | 23.68 ± 1.21 | 19.86 ± 1.16 |
130 | 18.66 ± 0.77 | 15.77 ± 2.34 | 17.40 ± 1.65 | 15.06 ± 3.32 | |
182 | 15.21 ± 2.86 | 11.77 ± 1.34 | 13.23 ± 1.68 | 13.45 ± 2.01 | |
He [mm] | 78 | 4.46 ± 0.11 | 4.41 ± 0.09 | 4.33 ± 0.06 | 4.28 ± 0.06 |
130 | 4.11 ± 0.03 | 4.03 ± 0.09 | 4.02 ± 0.07 | 3.99 ± 0.15 | |
182 | 3.87 ± 0.04 | 3.83 ± 0.04 | 3.84 ± 0.07 | 3.88 ± 0.05 | |
Fr [%] | 78 | 1.83 | 2.86 | 0.33 | 4.79 |
130 | 1.30 | 3.01 | 0.15 | 6.69 | |
182 | 3.23 | 0.83 | 0.23 | 5.07 | |
Di [min] | 78 | 0.13 ± 0.00 | 0.35 ± 0.02 | 0.27 ± 0.10 | 0.68 ± 0.07 |
130 | 0.28 ± 0.02 | 0.37 ± 0.03 | 1.72 ± 0.70 | 0.73 ± 0.12 | |
182 | 0.48 ± 0.13 | 0.55 ± 0.03 | 1.78 ± 0.70 | 0.72 ± 0.15 | |
T1 [min] | 78 | 0.12 ± 0.00 | 0.27 ± 0.02 | 0.70 ± 0.55 | 0.15 ± 0.02 |
130 | 0.28 ± 0.05 | 0.25 ± 0.07 | 0.97 ± 0.33 | 0.18 ± 0.02 | |
182 | 0.97 ± 0.40 | 0.60 ± 0.35 | 2.23 ± 1.40 | 0.15 ± 0.02 | |
T2 [min] | 78 | 0.22 ± 0.03 | 0.43 ± 0.05 | 1.25 ± 0.45 | 0.18 ± 0.00 |
130 | 0.53 ± 0.05 | 0.65 ± 0.17 | 2.90 ± 1.32 | 0.33 ± 0.07 | |
182 | 1.65 ± 0.60 | 1.20 ± 0.55 | 9.68 ± 5.05 | 0.28 ± 0.07 | |
WA [%] | 78 | 93.76 ± 3.85 | 59.59 ± 1.20 | 63.98 ± 5.75 | 36.57 ± 4.76 |
130 | 96.65 ± 3.11 | 66.28 ± 4.65 | 59.19 ± 5.55 | 38.83 ± 2.87 | |
182 | 101.13 ± 4.75 | 69.65 ± 2.49 | 60.90 ± 18.77 | 37.42 ± 5.28 |
CP—compression pressure; UM—uniformity of mass; RMS—surface topography and roughness; PD—pycnometric density; Po—porosity of tablets; He—height; Fr—friability; Di—disintegration; T1, T2—wetting time; WA—water absorption ratio.