Table 6.
Weighted ORs (95%CI) for scores on the Consortium to CERAD test, Animal Fluency test, DSST across quartiles of serum total 25(OH)D, 25(OH)D2 and 25(OH)D3, NHANES 2011–2014 (N = 2735).
| CERAD Test | Animal Fluency Test | Digit Symbol Test | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case/Participants | Crude | Model 1 | Model 2 | Case/Participants | Crude | Model 1 | Model 2 | Case/Participants | Crude | Model 1 | Model 2 | |
| Total 25-Hydroxyvitamin D (nmol/L) | ||||||||||||
| ≤61.41 | 274/911 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 326/911 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 307/911 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| ≤86.30 | 252/915 | 0.96 (0.77–1.20) | 0.94 (0.75–1.15) | 1.02 (0.77–1.34) | 259/915 | 0.75 (0.59–0.96) * | 0.75 (0.58–0.97) * | 1.12 (0.83–1.51) | 237/915 | 0.60 (0.44–0.81) * | 0.58 (0.43–0.80) * | 0.93 (0.61–1.42) |
| >86.30 | 194/909 | 0.68 (0.53–0.87) * | 0.67 (0.52–0.86) * | 0.77 (0.55–1.08) | 236/909 | 0.64 (0.47–0.88) * | 0.59 (0.44–0.81) * | 0.95 (0.70–1.28) | 177/909 | 0.44 (0.34–0.55) * | 0.41 (0.32–0.52) * | 0.68 (0.47–0.97) * |
| 25-Hydroxyvitamin D3 (nmol/L) | ||||||||||||
| ≤55.14 | 264/911 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 334/911 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 316/911 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| ≤80.63 | 266/913 | 1.16 (0.85–1.59) | 1.10 (0.81–1.48) | 1.23 (0.86–1.77) | 259/913 | 0.74 (0.56–0.99) * | 0.74 (0.56–0.98) * | 1.10 (0.92–1.46) | 238/913 | 0.61 (0.46–0.81) * | 0.58 (0.43–0.80) * | 0.92 (0.64–1.33) |
| >80.63 | 190/911 | 0.74 (0.53–1.03) | 0.72 (0.51–1.02) | 0.92 (0.58–1.45) | 228/911 | 0.61 (0.47–0.99) * | 0.57 (0.44–0.75) * | 0.98 (0.75–1.29) | 167/911 | 0.36 (0.29–0.46) * | 0.41 (0.32–0.52) * | 0.62 (0.44–0.86) * |
| 25-Hydroxyvitamin D2 (nmol/L) | ||||||||||||
| ≤1.45 | 516/2028 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 594/2028 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 527/2028 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| >1.45 | 204/707 | 1.27 (0.92–1.77) | 1.30 (0.93–1.81) | 1.47 (0.98–2.22) | 227/707 | 0.99 (0.74–1.33) | 0.97 (0.72–1.29) | 1.05 (0.74–1.47) | 194/707 | 0.95 (00.73–1.25) | 0.94 (0.70–1.26) | 1.00 (0.68–1.49) |
Binary logistic regression analyses were used to calculate weighted OR values. Reference (Ref.); model 1 adjusted for age and gender; model 2 adjusted for age and gender, race, educational level, marital status, income, body mass index (BMI), season of exam, physical activity level, drinking status, smoking status, hypertension, diabetes, and stroke. Energy was adjusted when we studied the intake of dietary VD. * p-value ≤ 0.05.