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. 2021 Sep 15;12(9):1106. doi: 10.3390/mi12091106

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Several representative physiological models of respiratory system based on lung-on-a-chip: (a) the lung-on-a-chip that simulates the breathing process through air pressure changes in the side channel produced by Huh et al.; (b) the lung-on-a-chip that simulates the breathing process through basement membrane deformation produced by Stucki et al.; (c) the lung-on-a-chip that can directly observe the position of particles produced by Fishler et al.; (d) the lung-on-a-chip with a special structure that simulates the contraction and relaxation of bronchial smooth muscle produced by Nesmith et al.. Reproduced with permission from [14,40,53,57].

Several representative physiological models of respiratory system based on lung-on-a-chip: (a) the lung-on-a-chip that simulates the breathing process through air pressure changes in the side channel produced by Huh et al.; (b) the lung-on-a-chip that simulates the breathing process through basement membrane deformation produced by Stucki et al.; (c) the lung-on-a-chip that can directly observe the position of particles produced by Fishler et al.; (d) the lung-on-a-chip with a special structure that simulates the contraction and relaxation of bronchial smooth muscle produced by Nesmith et al.. Reproduced with permission from [14,40,53,57].