Table 1.
Cancer classifications of some nitrosamines found in pharmaceutical drugs and structurally related N-nitrosomethylalkylamines (NMAs).
| Nitrosamine | Structure | Cancer Classification 1 |
|---|---|---|
| N-Nitrosodimethylamine (NDMA, NMA-C1) |
|
IARC 2A (1987) US EPA B2 (1986) NTP RoC RA (1981) P65 (1987) |
| N-Nitrosodiethylamine (NDEA) |
|
IARC 2A (1987) US EPA B2 (1986) NTP RoC RA (1981) P65 (1987) |
| N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) |
|
Not evaluated |
| N-Nitrosomethylethylamine (NMA-C2) N-Nitrosomethyl-n-propylamine (NMA-C3) N-Nitrosomethyl-n-butylamine (NMA-C4) N-Nitrosomethyl-n-pentylamine (NMA-C5) N-Nitrosomethyl-n-hexylamine (NMA-C6) N-Nitrosomethyl-n-heptylamine (NMA-C7) N-Nitrosomethyl-n-octylamine (NMA-C8) N-Nitrosomethyl-n-nonylamine (NMA-C9) N-Nitrosomethyl-n-decylamine (NMA-C10) N-Nitrosomethyl-n-undecylamine (NMA-C11) N-Nitrosomethyl-n-dodecylamine (NMA-C12) N-Nitrosomethyl-n-tetradecylamine (NMA-C14) |
 R: alkyl group (where C2 indicates a 2 carbon alkyl group, C3 indicates a 3 carbon alkyl group, and so on) |
NMA-C2: IARC 2B (1987) US EPA B2 (1988) P65 (1989) NMA-C3 through NMA-C12, and NMA-C14: P65 (2014) |
1 Cancer classification by various authoritative bodies. International Agency for Research on Cancer (IARC) Group 2A: probably carcinogenic to humans; IARC Group 2B: possibly carcinogenic to humans; US Environmental Protection Agency (US EPA) Group B2: probable human carcinogen; National Toxicology Program (NTP) Report on Carcinogens (RoC) RA, reasonably anticipated to be a human carcinogen; P65, California Proposition 65 (The Safe Drinking Water and Toxic Enforcement Act of 1986) carcinogen.