Skip to main content
. 2021 Sep 17;22(18):10027. doi: 10.3390/ijms221810027

Figure 2.

Figure 2

Co-treatment with metformin and DCA did not show cytotoxicity in primary normal hepatocytes. Primary normal hepatocytes were treated with the indicated concentrations of metformin and DCA for 24 h. (A) There was no cytotoxicity of DCA on primary normal hepatocytes even at high concentrations compared to the control. (B) At low concentrations of metformin (≤40 mM), there was no significant cytotoxicity of metformin on primary normal hepatocytes; at high concentrations of metformin (≥80 mM), cytotoxicity of metformin on primary normal hepatocytes significantly increased compared to the control. (C) Co-treatment with metformin and DCA did not show cytotoxicity in primary normal hepatocytes compared to the control. * p < 0.05 and *** p < 0.001.