Table 2.
Resistance phenotype and genotype present in the 24 CTX/CAZR Klebsiella pneumoniae isolates from clinical samples in a Portuguese hospital.
| Sample | Origin | Date (Month Year) | Antimicrobial Resistance Phenotype a | ESBL Production b |
β-lactamases | MLST c | Other Genes/Int d |
|---|---|---|---|---|---|---|---|
| X2175 | Urine | June 2017 | AMC, CTX, CAZ, IMP, MRP, ERT, CIP, SXT, S | P | CTX-M-15, KPC-2/3, SHV-12, TEM | ST15 | ND |
| X2143 | Urine | December 2016 | AMC, FOX, CTX, CAZ, IMP, MRP, ERT, TET, CIP, GEN, SXT, S | P | CTX-M-15, KPC-2/3, SHV-27, TEM | ST280 | tetA |
| X2153 | Urine | June 2017 | AMC, FOX, CTX, CAZ, IMP, MRP, ERT, TET, CIP, GEN, SXT, S | P | CTX-M-15, KPC-2/3, SHV-27, TEM | NT | tetA |
| X2155 | Urine | February 2017 | AMC, CTX, CAZ, IMP, MRP, ERT, TET, CIP, GEN, SXT, S | P | CTX-M-15, KPC-2/3, SHV-27, TEM | NT | tetA |
| X2166 | Urine | May 2017 | AMC, CTX, CAZ, IMP, MRP, ERT, TET, CIP, GEN, SXT, S | P | CTX-M-15, KPC-2/3, SHV-27, TEM | NT | tetA |
| X3098 | Urine | December 2016 | CTX, CAZ, TET, CIP, TOB, GEN, SXT, S | P | CTX-M-15, SHV-27 | NT | tetA |
| X3100 | Urine | March 2017 | CTX, CAZ, IMP, TET, CIP, TOB, SXT, S | P | CTX-M-15, SHV-27 | NT | tetA |
| X3104 | Urine | May 2017 | AMC, CTX, CAZ, IMP, MRP, ERT, TET, CIP, TOB, SXT, S | P | CTX-M-15, SHV-11 | NT | ND |
| X2157 | Urine | April 2017 | AMC, FOX, CTX, CAZ, IMP, MRP, ERT, CHF, CIP, GEN, SXT, S | P | CTX-M-15, KPC-2/3, SHV-28, TEM | ST15 | ND |
| X3095 | Urine | December 2016 | CTX, CAZ, MRP, TET, CIP, TOB, GEN, SXT, S | P | CTX-M-15, SHV-28 | NT | tetA |
| X3105 | Urine | May 2017 | AMC, CTX, CAZ, ERT, TET, CIP, TOB, GEN, SXT, S | P | CTX-M-15, SHV-28 | NT | tetA |
| X3106 | Urine | May 2017 | CTX, CAZ, ERT, TET, CIP, TOB, GEN, SXT, S | P | CTX-M-55, SHV-11 | NT | tetA |
| X2142 | Urine | December 2016 | AMC, FOX, CTX, CAZ, IMP, MRP, ERT, CHF, CIP, GEN, SXT, S | P | SHV-12, KPC-2/3, TEM | ST147 | ND |
| X3092 | Urine | December 2016 | AMC, CTX, CAZ, IMP, TET, TOB, CIP, GEN, SXT, S | P | SHV-12 | NT | ND |
| X3096 | Urine | December 2016 | CTX, CAZ, IMP, TET, CIP, SXT, S | P | SHV-12 | NT | tetA |
| X3097 | Urine | December 2016 | CTX, CAZ, IMP, TET, TOB, CIP, GEN, SXT, S | P | SHV-12 | NT | tetA |
| X3107 | Urine | May 2017 | AMC, FOX, ERT, CTX, CAZ, TET, CIP, SXT, S | P | SHV-12 | NT | tetA |
| X2232 | Urine | January 2017 | AMC, CTX, CAZ, IMP, MRP, ERT, TET, CIP, GEN, SXT, S | P | SHV-27, KPC-2/3, TEM | ST280 | tetA |
| X3085 | Bronchial secretion | December 2017 | AMC, FOX, CTX, CAZ, IMP, MRP, ERT, TOB, CIP, GEN, SXT, S | P | CTX-M-15, KPC-2/3, SHV-11 | NT | ND |
| X3094 | Pus | December 2017 | CTX, CAZ, TET, TOB, GEN, SXT, S | P | CTX-M-15, SHV-11 | NT | tetA |
| X3102 | Biopsy | May 2017 | AMC, CTX, CAZ, TOB, GEN, SXT, S | P | CTX-M-15, SHV-11 | NT | ND |
| X3087 | Bronchial secretion | December 2016 | AMC, FOX, CTX, CAZ, IMP, MRP, ERT, TET, TOB, CIP, GEN, SXT, S | P | CTX-M-15, SHV-27 | NT | tetA |
| X3088 | Bronchial secretion | June 2017 | AMC, CTX, CAZ, IMP, MRP, ERT, TOB, CIP, GEN, SXT, S | P | CTX-M-15, KPC-2/3, SHV-28 | NT | ND |
| X3101 | Catheter | April 2017 | AMC, CTX, CAZ, IMP, MRP, ERT, TET, TOB, CIP, SXT, S | P | CTX-M-55, SHV-11 | NT | tetA |
Legend:a AMC: amoxicillin + clavulanic acid; FOX: cefoxitin; CTX: cefotaxime; CAZ: ceftazidime; CHL: chloramphenicol; CIP: ciprofloxacin; TOB: tobramycin; GEN: gentamicin; SXT: trimethoprim + sulfamethoxazole; S: streptomycin; TET: tetracycline; IMP: imipenem; ERT: ertapenem; MRP: meropenem; b P—Positive, N—Negative; c MLST—MultiLocus Sequence Typing; d NT: not tested; ND: not detected.