Table 2.

Selected PK parameters following analysis for the steers administered 20 mg/kg florfenicol IM q48 h twice. The geometric mean and geometric CV% are provided. T_max: time to maximum concentration; C_max: the maximum drug concentration; AUC: area under the time–concentration curve.

		Plasma		ISF		Ileum Ultrafiltrate		Colon Ultrafiltrate
Parameter	Unit	Geometric Mean	Geometric CV%	Geometric Mean	Geometric CV%	Geometric Mean	Geometric CV%	Geometric Mean	Geometric CV%
Tmax	h	1.82	26.53	59.91	10.42	76.35	13.42	61.27	18.57
Cmax	µg/mL	2.33	48.66	1.37	25.01	2.88	39.34	3.16	82.81
AUC	h·µg/mL	56.46	42.03	98.58	60.31	140.75	24.73	168.45	76.96
Half-Life	h	15.06	46.21	41.58	75.33	29.28	5.5	17.69	63.68
Penetration	%			69.95	63.44	97.93	21.88	115.60	78.10