Table 2.

Selection of protein changes in published platelet proteomes. Confined to papers showing abundant regulated proteins in platelet (fractions from) patients. Italic: plasma or secretory proteins [11].

Aim of Study	No. of Regulated Proteins	Selection of Regulated Proteins	Ref.
3-BASIC. Proteomes of large and small platelets (1 subject)	80 up or down (9%)	ADP-ribosylation factor 1/3, GTP-binding protein SAR1a, guanylate cyclase soluble subunit α3, voltage-dependent anion channel protein 3, serotransferrin, immunoglobulins, haptoglobin, hemopexin, α1-antitrypsin, vitronectin	[27]
5-GPVI. Platelet proteome in Scott syndrome (1 patient)	134 up or down (6%)	anoctamin 6, annexin A5, calpain 1, protein S100-A8/9, channel aquaporin-1, pregnancy zone protein, myeloperoxidase, serine-pyruvate aminotransferase, platelet glycoprotein 4, cAMP-dependent protein kinase IIβ regulatory subunit	[28]
10-PAT. Platelet iloprost phosphoproteome of PHP Ia patients (6 patients)	51 up or down (11%)	phosphorylation of protein kinase A consensus sites: inositol triphosphate receptor associated 1/2, bridging integrator 2, vasodilator-stimulated phosphoprotein, coiled-coil domain-containing protein 9, claudin 5, consortin, Grb2-associated binding protein 2.	[29]
10-PAT. Platelet proteome in X-linked thrombocytopenia (5 patients)	83 up or down (4%)	prostaglandin G/H synthase 1, solute carrier family 35 member D3, carbonic anhydrase 2, peroxiredoxin 1, tubulin-tyrosine ligase-like protein 12, spectrin α-chain, nexilin, E2 ubiquitin-conjugating enzyme, proteasome subunit α/βtype 4, heat shock 70 kDa protein 1b	[30]
10-PAT. Platelet proteome in Gray platelet syndrome (5 patients)	123 up or down (% n.d.)	neurobeachin-like protein 2, SPARC, serglycin, latent-transforming growth factor β-binding protein 1, platelet basic protein, thrombospondin-1, platelet factor 4, multimerin-1, von Willebrand factor	[31]
10-PAT. Platelet proteome of patients with early-stage cancer (12 patients)	85 up or down (3%)	mitochondrial deoxyribonucleotidase and 39 S ribosomal protein, V-type proton ATPase subunit S1, myomegalin, serine/arginine repetitive matrix protein 2, CD34, peptidoglycan recognition protein 1, nuclear ribonucleoprotein A1, histone H2B type 1J, neurochondrin, calmodulin-dependent protein kinase type 1D	[19]