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Schematic representation of disulfide-bridged silica NPs for dual doxorubicin and p53 gene delivery. Doxorubicin is loaded in situ during the synthesis of the NPs, which are further modified with a polycation for gene condensation. Upon internalization, the NPs are destroyed by GSH, delivering the drug and the gene. Adapted with permission from [66]. Copyright Wiley, 2017.
