FIG. 8.

Both ErbB1 and ErbB2 homodimers are able to induce reversible morphological transformation of fibroblasts. The cells were plated in the presence of AP1510 (concentrations shown are nanomolar) and allowed to grow for 48 h. The morphologies of the cells were recorded (a to i and m to o). The cells in panels i and o were trypsinized and replated either in media without (j and p) or with AP1510 (k, l, q, and r). P75.F1 (Fig. 1B) corresponds to cells expressing the chimera without the ErbB cytoplasmic domain.