. 2021 Sep 8;13(18):4514. doi: 10.3390/cancers13184514

Table 3.

Patient characteristics associated with overall survival in multivariate Cox analyses.

Characteristics	OS (Months)	Cox 1		Cox 2
Characteristics	Median (95% CI)	HR (95% CI)	p	HR (95% CI)	p
Number of metastatic sites
≤2	8.6 (7.5–9.7)	0.6 (0.5–0.8)	<0.001	0.6 (0.5–0.8)	<0.001
≥3 ^a	5.6 (4.7–6.6)	0.6 (0.5–0.8)	<0.001	0.6 (0.5–0.8)	<0.001
Liver metastasis
No	10.7 (8.8–12.7)	0.7 (0.5–0.9)	0.004	-	-
Yes ^a	6.6 (5.6–7.5)	0.7 (0.5–0.9)	0.004	-	-
Alkaline phosphatase level
<300 IU	9.8 (8.5–11.0)	0.6 (0.4–0.8)	<0.001	0.5 (0.4–0.7)	<0.001
≥300 IU ^a	4.1 (2.5–5.7)	0.6 (0.4–0.8)	<0.001	0.5 (0.4–0.7)	<0.001
Dose reductions
Without dose reductions ^a	6.4 (5.1–7.6)	-	-	0.6 (0.4–0.8)	<0.001
With dose reductions	10.7 (8.8–12.7)	-	-	0.6 (0.4–0.8)	<0.001
Neutrophil/lymphocyte ratio
<5	9.0 (8.0–10.0)	-	-	0.5 (0.4–0.7)	<0.001
≥5 ^a	4.1 (3.0–5.1)	-	-	0.5 (0.4–0.7)	<0.001

CI: confidence interval, HR: hazard ratio, OS: overall survival. ^a Reference category.