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The potential protective role of anti-TNFs against COVID-19 is synthetically explained in this figure. Anti-TNFs have been shown to downregulate ACE2, leading to a most difficult virus entry into the cells. These drugs also have an anti-IL-6 activity, and this could contribute to the dampening of cytokine storm which is activated in most severe forms of COVID-19. ACE2: angiotensin converting enzyme 2. TNF: tumor necrosis factor.
