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. 2021 Sep 18;22(18):10083. doi: 10.3390/ijms221810083

Figure 7.

Figure 7

Association of EV CRP and SAA-1 in EVs with length of hospital stay in severe burn injury. EVs were isolated from 50 human burn patients and levels of CRP (A–D) and SAA1 (E–H) measured by ELISA and their association with length of stay (LOS) in the hospital were determined. (A) CRP levels from MV-depleted plasma showed no association with severity of burn injury. (B) CRP levels in EVs from human burn patients showed a positive correlation with severity of burn injury. r = 0.32, * p < 0.05. (C) CRP levels in EVs of male human burn patients was not related to LOS. (D) CRP concentration in EVs from female burn patients was positively correlated with hospital LOS (r = 0.56, * p < 0.05). (E) SAA1 protein concentration in MV-depleted plasma showed no association with severity of burn injury. (F) SAA1 concentrations in EVs from human burn patients showed a positive correlation with severity of burn injury. r = 0.33, * p < 0.05. (G) SAA1 concentrations in EVs of male human burn patients was not related to LOS. (H) SAA1 concentration in EVs from female burn patients was positively correlated with hospital LOS (r = 0.58, * p < 0.05). (I) Concentrations of CRP and SAA1 in EVs were significantly correlated with each other. r = 0.39, * p < 0.02.