Table 4.
Anticarcinogenic activity of peptides derived from secondary raw materials from fish processing.
| By-Product Source for Peptide | Peptide Sequence/Molecular Weight | Anticancer Effect | Researchers |
|---|---|---|---|
| Sepia Ink oligopeptides due to presence of lysine and proline in sequence | N Gln-Pro-Lys with a molecular mass of 343.4 Da |
Inhibition of proliferation of human prostate cancer (DU-145) cells |
[118] |
| Tuna dark muscle peptides | Leu-Pro-His-Val-Leu-Thr-Pro-Glu-Ala-Gly-Ala-Thr and Pro-Thr-Ala-Glu-Gly-Gly-Val-Tyr-Met-Val-Thr) |
Anticarcinogenic activity against breast cancer cell line | [24] |
| Snow crab by-product peptides | Two anionic peptides with MW of 537 and 216 Da and three cationic peptides with MW of 228, 241 and 291 Da | anticancer activity on colon, breast, prostate and lung cancer cell lines |
[119] |
| Shrimp shell peptide | Peptides with fractionation size < 10 and 10–30 kDa | Anticancer activity on colon and liver cancer cell lines | [120] |
| Flathead by-product peptides | <3 kDa | Anticancer activity against HT-29 colon cancer cells up to 91.04% | [121] |
| Lates calcarifer skin peptides | - | Anti-proliferative activity on human colon and liver cancer cell lines | [117] |
| Flying fish frame peptides | - | Anti-proliferative activity against Hep G2 cells |
[122] |
| Grouper roe peptides | - | Reduced cell viability of oral cancer cells & induced apoptosis of Ca9–22 cells |
[123] |
| Rohu roe peptides | - | Anti-proliferative activity on Human colon cancer cell line |
[124] |
| Threadfin bream (Nemipterus japonicus) Back bone peptides |
- | Anti-proliferative activity against HepG2 cell lines |
[24] |
| Cuttlefish mantle protein hydrolysates | - | MDA-231 and T47D cancer cell lines with growth inhibition of 78.2 and 66.2% | [125] |
| Gilthead seabream byproduct peptides | - | Antiproliferative activity on human colon and breast cancer cell lines | [126] |