Table 2.
(A) Unique genes showing strong correlation with plasma miRNAs (ρ ≥ |0.7|, P < 6.9 × 10−5). Additional miRNAs with ρ ≥ |0.6| and direction of differentially expressed genes (DEG; preserved OA cartilage versus healthy cartilage) are shown. (B) Correlations (left) and matrix (right) of genes strongly correlating to at least 10 plasma miRNAs (indicated in bold in (A).
| A | ||||||
| miRNA | Gene | Corr. | P | Additional miRNAs (ρ ≥ |0.6|) |
Cartilage
DEG
(P vs. H) |
|
| let-7d-5p | EGFLAM | −0.75 | 6.8 × 10−5 | let-7f-5p; let-7a-5p; miR-4443; miR-221-5p; miR-3615; miR-200b-3p; let-7e-5p; miR-1180-3p; let-7g-5p | dn | |
| miR-3928-3p | PDGFRL | −0.74 | 9.0 × 10−5 | miR-1260a; miR-106b-5p; 6852-5p; miR-23b-5p | up | |
| let-7a-5p | THADA | −0.73 | 1.0 × 10−4 | miR-339-3p; miR-22-3p | dn | |
| miR-145-3p; miR-23b-3p | HMGB2 | −0.71 | 2.3 × 10−4 | miR-181a-3p; miR-425-3p; miR-7849-3p; miR-326; miR-339-5p; miR-133a-3p; miR-3613-5p; miR-335-5p; miR-421 | dn | |
| miR-19b-3p | GLI3 | −0.71 | 2.4 × 10−4 | miR-3909; miR-23b-5p; miR-181a-5p; miR-4755-5p | up | |
| miR-494-3p | SMIM3 | 0.71 | 2.5 × 10−4 | miR-889-3p; miR-411-3p; miR-224-5p; miR-379-5p; miR-4326; miR-222-3p; miR-431-5p; miR-12136; miR-382-5p; miR-329-3p; miR-495-3p; miR-505-3p; miR-221-5p; miR-7849-3p; miR-30b-3p; miR-6772-3p; miR-493-5p; miR-381-3p | dn | |
| miR-106b-5p | COPZ2 | 0.70 | 2.7 × 10−4 | miR-939-3p; miR-210-3p | up | |
| B | ||||||
| Gene | Gene | Corr. | P | |||
| HMGB2 | SMIM3 | −0.39 | 7.0 × 10−2 | |||
| CTHRC1 | SMIM3 | −0.31 | 1.7 × 10−1 | |||
| CTHRC1 | EGFLAM | 0.22 | 3.2 × 10−1 | |||
| CTHRC1 | HMGB2 | 0.22 | 3.3 × 10−1 | |||
| EGFLAM | HMGB2 | 0.19 | 4.0 × 10−1 | |||
| EGFLAM | SMIM3 | −0.10 | 6.5 × 10−1 | |||
| CTHRC1 | EGFLAM | HMGB2 | SMIM3 | |||
| CTHRC1 | 1.00 | |||||
| EGFLAM | 0.22 | 1.00 | ||||
| HMGB2 | 0.22 | 0.19 | 1.00 | |||
| SMIM3 | −0.31 | −0.10 | −0.39 | 1.00 | ||