Table 1.

Histopathology findings and histological inflammation scores at baseline and after 8 weeks of treatment. Biopsies were collected from the stomach, duodenum, ileum and colon. Scores range from 0 to 3, where 0 = no inflammation, 1 = mild inflammation, 2 = moderate inflammation, and 3 = severe inflammation. No significant difference was found between baseline and 8 weeks (paired t-test, p = 0.096). Mild-mod = mild-to-moderate; L = lymphocytic; P = plasmacytic; LP = lymphocytic-plasmacytic; IELs = intra-epithelial lymphocytes.

Patient and Time Point	Histopathologic Diagnosis	Cellular Infiltrates	Mucosal Architecture	Inflammation Scores
Dog 1 Baseline	Mild-mod LP gastritis; mild-mod LP enteritis	Lymphocytes, plasma cells	No abnormalities	3
8 weeks	Mild-mod LP gastritis; mod-severe LP enteritis	Lymphocytes, plasma cells, eosinophils	Multi-focal lacteal dilation	1
Dog 2 Baseline	Moderate L gastritis; moderate LP enteritis; mild L colitis	Lymphocytes, plasma cells	Lacteal dilation; crypt hyperplasia	2
8 weeks	Mild L gastritis; mild LP enteritis; mild LP colitis	Lymphocytes, plasma cells	Lacteal dilation; crypt hyperplasia	1
Dog 3 Baseline	Moderate LP enteritis; mild L colitis	Lymphocytes, plasma cells	Lacteal dilation; multi-focal crypt abscesses	1
8 weeks	Mild-mod LP enteritis; mild LP colitis; intestinal lymphangiectasia	Lymphocytes, plasma cells	Lacteal dilation	1
Dog 4 Baseline	Severe L gastritis with fibrosis; severe L enteritis; moderate L colitis	Lymphocytes	Gastric fibrosis; multi-focal dilated lacteals; increased IELs; crypt hyperplasia; diffuse villus blunting; increased goblet cells	1
8 weeks	Severe LP gastritis; mild-mod LP enteritis; mild LP colitis	Lymphocytes, plasma cells, neutrophils	Tortuous colonic glands	0
Dog 5 Baseline	Mild LP gastritis; mild-mod LP enteritis	Lymphocytes, plasma cells	Multi-focal dilated lacteals	1
8 weeks	Mild LP enteritis; mild LP colitis	Lymphocytes, plasma cells	No abnormalities	2
Dog 6 Baseline	Moderate LP enteritis	Lymphocytes, plasma cells	No abnormalities	1 0
8 weeks	Mild LP gastritis; moderate LP enteritis; moderate LP colitis	Lymphocytes, plasma cells	No abnormalities
Dog 7 Baseline	Mild LP gastritis; mod plasmactyic enteritis; mild LP colitis	Lymphocytes, plasma cells	Gastric edema; multi-focal crypt abscesses; hyperplasia of colonic glandular epithelium	2
8 weeks	Mild LP gastritis; mild-mod LP enteritis; mild LP colitis	Lymphocytes, plasma cells	Multifocal lacteal dilation; multi-focal crypt abscesses	1
Dog 8 Baseline	Mild-mod LP enteritis	Lymphocytes, plasma cells	No abnormalities	1
8 weeks	Moderate P enteritis; moderate P colitis with fibrosis	Plasma cells	Multi-focal lacteal dilation; mild colonic fibrosis	1
Dog 9 Baseline	Moderate LP gastritis; moderate LP enteritis	Lymphocytes, plasma cells	Multifocal lacteal dilation; multifocal crypt abscesses	2
8 weeks	Moderate LP gastritis; moderate LP enteritis	Lymphocytes, plasma cells	No abnormalities	2