Table 3.
Selected fecal metabolites identified by untargeted metabolomics that were significantly different in dogs with SRE (complete list available in Table S3). Compound type, direction of change compared to healthy controls (HC), as well as the time points at which changes were statistically significant are indicated, as well as overall p-values and adjusted p-values (FDR). NIST = National Institute of Standards and Technology.
| Compound Name | Compound Type | Change in Relation to HC | Time Points Significantly Different from HC | p-Value | FDR |
|---|---|---|---|---|---|
| alanine | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| asparagine | amino acid | increased | baseline | 0.001 | 0.006 |
| aspartic acid | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| cysteine | amino acid | increased | baseline | 0.009 | 0.029 |
| cystine | amino acid | increased | baseline | 0.001 | 0.003 |
| glutamic acid | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| glycine | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| isoleucine | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| leucine | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| lysine | amino acid | increased | 3 weeks, 8 weeks | 0.012 | 0.037 |
| methionine | amino acid | increased | baseline, 3 weeks, 8 weeks, long term | 0.000 | 0.000 |
| phenylalanine | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.002 |
| proline | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| serine | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| threonine | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| tryptophan | amino acid | increased | baseline, 3 weeks, 8 weeks, long term | 0.000 | 0.001 |
| valine | amino acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| glycyl tyrosine | dipeptide | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| glycyl-proline | dipeptide | increased | baseline | 0.012 | 0.037 |
| homocystine | dipeptide | increased | baseline | 0.018 | 0.048 |
| glucose | glucose | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.002 |
| 6-deoxyglucose | glucose metabolite | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.002 |
| gluconic acid | glucose metabolite | increased | baseline | 0.012 | 0.036 |
| myo-inositol | glucose metabolite | increased | baseline | 0.000 | 0.001 |
| ribose | glucose metabolite | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.002 |
| indole-3-lactate | indole | decreased | 3 weeks, 8 weeks, long term | 0.000 | 0.002 |
| isothreonic acid | metabolite vitamin C | increased | baseline | 0.005 | 0.019 |
| threonic acid | metabolite vitamin C | increased | baseline, long term | 0.003 | 0.014 |
| fructose | monosaccharide | increased | baseline, 8 weeks | 0.000 | 0.003 |
| N-acetyl-D- mannosamine | monosaccharide | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.000 |
| tagatose | monosaccharide | increased | baseline | 0.006 | 0.022 |
| xylulose NIST | monosaccharide | increased | baseline, 3 weeks, 8 weeks | 0.003 | 0.011 |
| arachidonic acid | omega 6 fatty acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.002 |
| arachidic acid | saturated fatty acid | increased | baseline, 3 weeks | 0.002 | 0.009 |
| caprylic acid | saturated fatty acid | increased | baseline, 3 weeks | 0.001 | 0.006 |
| isoheptadecanoic acid NIST | saturated fatty acid | increased | baseline, 8 weeks | 0.006 | 0.022 |
| lauric acid | saturated fatty acid | increased | baseline, 3 weeks, 8 weeks | 0.000 | 0.001 |
| lignoceric acid | saturated fatty acid | increased | baseline | 0.001 | 0.005 |
| myristic acid | saturated fatty acid | increased | 3 weeks | 0.019 | 0.050 |
| palmitic acid | saturated fatty acid | increased | baseline | 0.018 | 0.048 |
| stearic acid | saturated fatty acid | increased | baseline, 3 weeks | 0.000 | 0.001 |
| nicotinic acid | vitamin B3 | increased | 3 weeks, 8 weeks | 0.002 | 0.008 |
| tocopherol delta- NIST | vitamin E | increased | 3 weeks, 8 weeks | 0.012 | 0.036 |
| tocopherol gamma- | vitamin E | increased | 3 weeks, 8 weeks, long term | 0.000 | 0.002 |