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Schematic illustration presenting brief mechanism of DC-based cancer vaccine. After vaccination with TAA-related payloads encapsulating NPs, TAA can be delivered into DCs and processed. Naïve T cells (CD4+/CD8+) are primed through presented TAA peptides on MHC I/II molecules of activated DCs. Naïve CD4+/CD8+ T cells differentiated to the Th cell and Tc cell respectively. Functional Th and Tc cells attack specific tumor cells expressing TAA presented by DCs.
