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. 2021 Sep 16;22(18):10013. doi: 10.3390/ijms221810013

Figure 4.

Figure 4

Effects of subchronic administration of 5-HT receptor agents, 5-HT1AR agonist, BP554 (BP: 50 μM), 5-HT1AR antagonist, WAY100635 (WAY: 10 μM), 5-HT7R inhibitor, SB269970 (SB: 10 μM), therapeutic-relevant concentration of escitalopram (ESC: 200 nM) and vortioxetine (VTX: 200 nM) on Cx43 protein expression in the cytosol (A) and plasma membrane (B) fractions. In left side histograms, ordinate: mean ± SD (n = 6) of the relative protein level of Cx43 per glyceraldehyde 3-phosphate dehydrogenase (GAPDH). ** p < 0.01: relative to control by student t-test or one-way ANOVA with Tukey’s post hoc test. @@ p < 0.01: relative to vortioxetine alone (VTX) by one-way ANOVA with Tukey’s post hoc test. Right side panels indicate their pseudo-gel images, using capillary immunoblotting.