Table 1.
Prevalence of human herpesvirus DNA in colonic mucosa of patients with inflammatory bowel disease.
| Scheme | Location | Duration | Study Design | Cohort | Samples | Methods | Results |
|---|---|---|---|---|---|---|---|
| Van Kruiningen HJ et al., 2007 [24] |
Belgium and France | Data unknown | Data unknown | CD: 70 Ctrl: 41 |
Surgical resection specimens | Conventional PCR | CD HSV-1: 0% HSV-2: 0% EBV: 15.7% CMV: 1.4% HHV-8: 0% Ctrl HSV-1: 0% HSV-2: 0% EBV: 7.3% CMV: 2.4% HHV-8: 0% |
| Ciccocioppo R et al., 2016 [25] |
Italy | Data unknown | Prospective | Responder IBD: 30 Refractory IBD: 20 (UC: 35, CD: 15) Ctrl: 25 |
Colonic LPMCs | Real-time PCR | Responder IBD EBV: 66% CMV: 28% Refractory IBD EBV: 100% CMV: 48% Ctrl EBV: 28% CMV: 20% |
| Shimada T et al., 2017 [26] |
Japan | 2011–2015 | Retrospective | IBD: 41 (UC: 33, CD: 8) |
Mucosal biopsy samples from colon | Real-time PCR | IBD HSV-1: 0% HSV-2: 0% VZV: 0% EBV: 53.7% CMV: 24.4% HHV-6: 39% HHV-7: 39% HHV-8: 0% |
| Hosomi S et al., 2018 [8] |
Japan | 2007–2010 | Retrospective | UC: 66 CD: 54 Ctrl: 29 |
Mucosal biopsy samples/ mucosa from surgical resected specimens |
Multiplex PCR | UC HSV-1/2: 0% VZV: 0% EBV: 21.2% CMV: 15.2% HHV-6: 9.1% HHV-7: 1.5% CD HSV-1/2: 0% VZV: 0% EBV: 9.3% CMV: 0% HHV-6: 9.3% HHV-7: 3.7% Ctrl HSV-1/2: 0% VZV: 0% EBV: 0% CMV: 3.4% HHV-6: 6.9% HHV-7: 0% |
CD: Crohn’s disease, CMV: cytomegalovirus, Ctrl: control, EBV: Epstein-Barr virus, HHV: human herpesvirus, HSV: herpes simplex virus, IBD: inflammatory bowel disease, LPMCs: lamina propria mononuclear cells, PCR: polymerase chain reaction, UC: ulcerative colitis, VZV: varicella-zoster virus.