Scheme 2.

PCP Treatment Model. After exposure to P. murina (Pm) and immunosuppression for 6 weeks, 10 control (untreated, “C/S”) mice were sacrificed to evaluate organism burden. Forty mice were randomized and rezafungin treatment was initiated. After 2 weeks of treatment (red box and “8 weeks” arrow) 10 mice were sacrificed as well as the remaining C/S mice. Lungs were homogenized and evaluated for organism burden. Time points are indicated by the arrows on top of the boxes. Treatment length (TX) is indicated in each box (2-, 4-, 6-, 8 weeks).