Table 1.
Large clinical studies that analyze the rate of intraoperative flap complications in manual and femtosecond flap creation. The total risk of complications is stated only if calculated within the study.
| Study | Method for Flap Creation | Number of Eyes * | Free Cap | Incomplete Flap | ButtonHole | Thin | Thick | Irregular Flap | Suction Loss | Epithelial Gas BreakThrough | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Stulting et al., 1999 [72] | manual (Chiron Automated Corneal Shaper) | 1244 ** (M) | 0.5% | 0.1% | 0.1% | 0.1% | 0.0% | ||||
| Lin and Malloney 1999 [49] | manual (Chiron Automated Corneal Shaper) | 1019 (M) | 1.0% | 0.3% | 0.9% | ||||||
| Tham and Moloney 2000 [46] | manual (Bausch and Lomb Hansatome or Automated Corneal Shaper) | 3988 (N/A) | 0.1% | 0.2% | 0.1% | 0.2% | 0.1% | ||||
| Jacobs and Taravella 2002 [48] | manual (Bausch and Lomb Hansatome or Automated Corneal Shaper) | 84,711 (N/A) | 0.0% | 0.1% | 0.1% | 0.1% | 0.0% | ||||
| Nakano et al., 2004 [51] | manual (Nidek MK-2000, Bausch and Lomb Hansatome and Automated Corneal Shaper) | 34,182 | 0.08% | 0.23% | 0.13% | ||||||
| Carrillo et al., 2005 [53] | manual (Nidek MK-2000) | 26,600 | 0.086% | 0.049% | 0.049% | 0.019% | 0.019% | ||||
| Albeda-Vallés et al., 2007 [50] | manual (Moria LSK-1) | 34,099 (M/H) | 1.67% | 0.36% | 0.11% | 0.82% | 0.93% | ||||
| Al-Mezaine et al., 2011 [47] | manual (Bausch and Lomb Hansatome and Moria LSK2) | 4352 (M/H) |
0.1% | 0.6% | 0.2% | 0.1% | |||||
| Haft et al., 2009 [55] | femtosecond (AMO IntraLase 15 and 30 kHz) | 4772 (N/A) |
0.06%# | 0.02% | 0.06%# | 0.25% |
* preoperative refractive error, if stated (M)—Myopia; (H)—Hyperopia; ** 182 LASIK enhancement procedures were included in the analysis (not possible to exclude this group from the analysis), # due to suction loss.