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. 2021 Aug 31;11(9):1588. doi: 10.3390/diagnostics11091588

Table 2.

Large clinical studies that analyze the rate of postoperative complications in manual and femtosecond laser flap creation. The total risk of complications is stated only if calculated within the study.

Study Method for Flap Creation Number of Eyes * Flap Displacement Epithelial Ingrowth Local Keratitis (Culture Positive or Negative) Flap Folds DLK TLSS
Stulting et al., 1999 [72] manual (Chiron Automated Corneal Shaper) 1062 + 182 * (only myopic) 0.4% (partial in 0.6%) 1.8% 0.2% 0.2%
Lin and Maloney 1999 [49] manual (Chiron Automated Corneal Shaper) 1019 2.0% 2.2% 1.1% 1.8%
Recep et al., 2000 [101] manual (Moria micokeratome) 1481 1.42%
Clare et al., 2011 [87] manual (Moria One Use-Plus) 23,997 0.033% **
Muñoz et al., 2006 [82] femtosecond (AMO IntraLase 15 and 30 kHz) 765 1.3%
Stonecipher et al., 2006 [81] femtosecond (IntraLase) 5667 1.1%
Sutton and Hodge 2008 [102] femtosecond (AMO IntraLase 15 and 30 kHz) 1000 0.4% 0.0% 0.0% 0.2% 0.0%
Haft et al., 2009 [55] femtosecond (AMO IntraLase 15 and 30 kHz) 4772 0.42% 0.25%
Clare et al., 2011 [87] femtosecond (IntraLase FS-60) 57,241 0.003% **
de Paula et al., 2012 [78] femtosecond (AMO IntraLase 60 kHz) 801 12.4%
Tomita et al., 2013 [76] femtosecond (Femto LDV–IntraLase 60 kHz) 818 8.17% –37.5%

* LASIK enhancement procedures; ** difference statistically significant, and more common in hyperopia. One eye lost 2 lines of BCVA. Abbreviations: DLK—diffuse lamellar keratitis; TLSS—transient light sensitivity syndrome.