Table 3.
Estimation of the risk of progression to high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 2–3 or cervical carcinoma (HSIL/CIN2+) according to age, smoking habit, colposcopy findings, Pap smear result, histological diagnosis and HPV16 E7 mRNA expression results at first visit.
| Univariate Analysis | |||
|---|---|---|---|
| Results at First Visit | HR | (95% CI) | p |
| Age | |||
| ≤35 years | 1 | ||
| >35 years | 1.8 | (0.7–7.4) | 0.431 |
| Smoking habit | |||
| Non-smoker | 1 | ||
| Smoker | 0.8 | (0.3–3.4) | 0.803 |
| Pap smear | |||
| Negative | 1 | ||
| LSIL | NA | 0.947 | |
| HSIL | NA | 0.945 | |
| Histological diagnosis | |||
| Negative | 1 | ||
| LSIL/CIN1 | 0.5 | (0.1–2.3) | 0.340 |
| Colposcopy findings | |||
| No abnormal findings | 1 | ||
| Abnormal findings grade 1 | 0.3 | (0.1–1.6) | 0.171 |
| Abnormal findings grade 2 | 1.1 | (0.2–6.7) | 0.898 |
| HPV16 E7 mRNA expression | |||
| Negative | 1 | ||
| Positive | 10.0 | (1.2–81.4) | 0.031 |
HSIL/CIN2+: high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 2–3 or cervical carcinoma; LSIL: low-grade intraepithelial squamous lesion; HPV16 E7 mRNA: human papillomavirus 16 E7 messenger RNA; HR: Hazard ratio; CI: confidence interval; NA: not applicable (since no women with negative cytology progressed to HSIL/CIN2+, the risk of progression could not be estimated).