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. 2021 Aug 24;13(9):1325. doi: 10.3390/pharmaceutics13091325

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of observed Cmax and AUC (AUC_0–t or AUC_tau) from different published studies [67,68,70,71,72,73,74,75,76,77,78] with final model simulations for studies used for model development (A,B) and model validation (C,D). Circles represent fasted studies, triangles represent studies where dolutegravir was administered with a moderate-fat meal, closed symbols represent single dose data, and open symbols represent steady-state data. In each plot, the solid line represents the identity line, and the dashed lines show margins for 1.5-fold errors. AUC = the area under the plasma concentration–time curve, AUC_0–t = AUC from time zero to t, AUC_tau = AUC during the dosing interval, and Cmax = maximum observed total plasma concentration.

Comparison of observed Cmax and AUC (AUC_0–t or AUC_tau) from different published studies [67,68,70,71,72,73,74,75,76,77,78] with final model simulations for studies used for model development (A,B) and model validation (C,D). Circles represent fasted studies, triangles represent studies where dolutegravir was administered with a moderate-fat meal, closed symbols represent single dose data, and open symbols represent steady-state data. In each plot, the solid line represents the identity line, and the dashed lines show margins for 1.5-fold errors. AUC = the area under the plasma concentration–time curve, AUC_0–t = AUC from time zero to t, AUC_tau = AUC during the dosing interval, and Cmax = maximum observed total plasma concentration.