Table 1.
GSEA identified GO pathways enriched with the Aβ42 proteome data set.
| GO ID # | Pathway Name | p-Value | # Entities Overlap |
|---|---|---|---|
| BIOLOGICAL PROCESS | |||
| GO:0051503 | adenine nucleotide transport | 2.41 × 10−2 | 8 |
| GO:0015868 | purine ribonucleotide transport | 2.41 × 10−2 | 8 |
| GO:0015865 | purine nucleotide transport | 2.41 × 10−2 | 8 |
| GO:0006862 | nucleotide transport | 2.41 × 10−2 | 8 |
| GO:1902475 | L-alpha-amino acid transmembrane transport | 1.97 × 10−2 | 5 |
| GO:1903825 | organic acid transmembrane transport | 4.85 × 10−2 | 11 |
| GO:1905039 | carboxylic acid transmembrane transport | 4.85 × 10−2 | 11 |
| GO:0015748 | organophosphate ester transport | 3.71 × 10−2 | 12 |
| GO:0001889 | liver development | 4.33 × 10−2 | 6 |
| GO:1901565 | organonitrogen compound catabolic process | 4.10 × 10−2 | 18 |
| GO:0032774 | RNA biosynthetic process | 3.83 × 10−2 | 10 |
| GO:2000113 | negative regulation of cellular macromolecule biosynthetic process | 4.64 × 10−2 | 19 |
| GO:0045892 | negative regulation of transcription, DNA-templated | 3.94 × 10−2 | 15 |
| GO:0051252 | regulation of RNA metabolic process | 3.47 × 10−2 | 44 |
| CELLULAR COMPONENT | |||
| GO:0005762 | mitochondrial large ribosomal subunit | 4.86 × 10−2 | 5 |
| GO:0000315 | organellar large ribosomal subunit | 4.86 × 10−2 | 5 |
| GO:0005840 | ribosome | 2.88 × 10−2 | 8 |
| GO:0098687 | chromosomal region | 1.52 × 10−2 | 6 |
| GO:1990904 | ribonucleoprotein complex | 2.32 × 10−2 | 14 |
| GO:0000785 | chromatin | 6.42 × 10−3 | 8 |
| MOLECULAR FUNCTION | |||
| GO:0000295 | adenine nucleotide transmembrane transporter activity | 2.41 × 10−2 | 8 |
| GO:0015216 | purine nucleotide transmembrane transporter activity | 2.41 × 10−2 | 8 |
| GO:0015215 | nucleotide transmembrane transporter activity | 2.41 × 10−2 | 8 |
| GO:0005346 | purine ribonucleotide transmembrane transporter activity | 2.65 × 10−2 | 7 |
| GO:0015605 | organophosphate ester transmembrane transporter activity | 2.41 × 10−2 | 8 |
| GO:0015932 | nucleobase-containing compound transmembrane transporter activity | 2.41 × 10−2 | 8 |
| GO:1901505 | carbohydrate derivative transmembrane transporter activity | 2.65 × 10−2 | 7 |
| GO:0008514 | organic anion transmembrane transporter activity | 4.34 × 10−2 | 13 |
| GO:0008134 | transcription factor binding | 3.53 × 10−2 | 8 |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | 1.40 × 10−2 | 9 |