Figure 7.
In vivo deposition amount of nafamostat mesylate (NFM) solution by administration route after administration of 10mg kg−1 NFM in Sprague–Dawley rats. (A) Amount of NFM in the bronchoalveolar lavage fluid (BALF) indicating amount of NFM in the lung lumen (mean ± standard error, n = 4), (B) Amount of NFM in lung tissue (mean ± standard error, n = 4). ITI: intratracheal instillation; IV: intravenous; ITI-1: without lecithin; ITI-2: with lecithin. * ANOVA, p-value < 0.05 compared with IV group; ** ANOVA, p-value < 0.005 compared with IV group; ## ANOVA, p-value < 0.005 compared with ITI-1 group.