Table 1.

Yield and particle size distribution of nafamostat mesylate (NFM) microparticles (mean ± standard deviation, n = 3). SD-NM: spray dried NFM and mannitol (1:100); SD-NLM1: spray dried NFM, lecithin and mannitol (1:1:100); SD-NLM2: spray dried NFM, lecithin and mannitol (1:1:50); SD-NLM3: spray dried NFM, lecithin, and mannitol (1:1:10).

Results	SD-NM 1:1 (w/w)	SD-NLM1 1:1:100 (w/w)	SD-NLM2 1:1:50 (w/w)	SD-NLM3 1:1:10 (w/w)
Yield (%)	42.1	44.7	21.5	5.1
Dv10 (μm)	0.27 ± 0.002	1.36 ± 0.000	0.29 ± 0.001	1.35 ± 0.055
Dv50 (μm)	2.40 ± 0.021	2.60 ± 0.010	2.58 ± 0.015	10.27 ± 0.153
Dv90 (μm)	4.99 ± 0.090	4.87 ± 0.065	10.93 ± 0.252	103.47 ± 4.319
Span	1.97 ± 0.021	1.35 ± 0.022	4.13 ± 0.082	9.96 ± 0.246