Table 3.
Pharmacokinetic parameters of NFM solution (mean ± standard error, n = 4).
| Results | IV | ITI-1 | ITI-2 |
|---|---|---|---|
| AUC(inf) (min· μg mL−1) | 436.1 ± 31.59 | 675.7 ± 50.83 * | 730.0 ± 67.84 ** |
| Cmax (μg mL−1) | 43.7 ± 7.98 | 25.9 ± 4.23 | 22.9 ± 4.64 * |
| Tmax (min) | - | 4.0 ± 1.00 | 10.3 ± 6.65 |
| T½ (min) | 13.2 ± 0.52 | 26.7 ± 2.60 ** | 28.6 ± 3.51 ** |
* ANOVA, p-value < 0.05 compared with IV; ** ANOVA, p-value < 0.005 compared with IV.; AUCinf: area under the curve from dosing to time infinity; Cmax: maximum plasma concentration; ITI: intratracheal instillation; IV: intravenous; ITI-1: without lecithin; ITI-2: with lecithin; Tmax: time to maximum plasmatic concentration; T½ plasmatic half-life.