Table 1.

Physiological and therapeutic actions of amygdalin.

Dose of Amygdalin	Treatment Time	Experimental Model	Actions	Ref.
		In vivo studies
1, 3, 10 mg/kg/day i.p.	4 weeks	mice	protective effect against atherosclerosis	[9]
5 mg/kg/week i.p.	3 weeks	mice	protective effect against autoimmune hepatitis	[54]
0.1, 0.5, 1 mg/kg i.m.	30 min	rats	analgesic effect	[17]
50, 100 mg/kg orally	2 weeks	mice	antioxidant effect	[38]
0.5, 1, 2 mg/kg i.p.	1 h	mice	anti-inflammatory effect	[47]
2, 4, 8 mg/kg i.p., twice (12 h interval)	48 h	mice	anti-inflammatory effect	[48]
320 mg/kg every 2 days, i.t.	17 days	C57BL/6 mice	anti-tumor effect	[55]
		In vitro studies
200 µmol/L	24 h	premature rats AECII	protective effect against lung injury	[33]
200 μg/mL	48 h	rat hepatic stellate cells	anti-fibrotic effect	[46]
10−8 and 10−6 M	48 h	human keratinocyte cells	immunomodulatory effect	[49]
65 mmol/L	48 h	human breast cancer cells	anti-tumor effect	[44]
2.5 and 5 mg/mL	48 h	human lung carcinoma cells	anti-tumor effect	[45]
10 mg/mL	24 h	mouse prostate cancer cells, human prostate cancer cells	anti-tumor effect	[55]
10 mg/mL	24 h	renal carcinoma cells, bladder cancer cells, prostate cancer cells	anti-tumor effect	[41,56,57,58]